Denise M. Ney, Ph.D.Professor of Nutritional Sciences B.S. 1975, University of California-Davis Emphasis Group Human Nutrition Principal Research Interest Gastrointestinal physiology and nutrient-hormone interactions. Wisconsin Public TV story of PKU nutrition research with GMP(Scroll down to PKU Trials and click on video.) TPN is a vital feeding technique for individuals who are unable to tolerate oral nutrition due to intestinal failure or catabolic illness.
Representative Publications Ney, D.M., Hull, A.K., van Calcar, S.C., Liu, X. and Etzel, M.R. Dietary glycomacropeptide supports growth and reduces the concentrations of phenylalanine in plasma and brain in a murine model of phenylketonuria. J. Nutr. 138:R316-R322, 2008. Koopmann, M.C., Nelson, D.W., Murali, S.G., Liu, X., Brownfield, M.S., Holst, J.J. and Ney, D.M. Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats. J. Parenter. Enteral Nutr. 32:R254-R265, 2008. Nelson, D.W., Murali, S.G., Liu, X., Koopmann, M.C., Holst, J.J., and Ney, D.M. Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats. Am. J. Physiol. 294:R1175-R1184, 2008. Nelson, D.W., Sharp, J.W., Brownfield, M.S., Raybould, H.E. and Ney, D.M. Localization and Murali, S.G., Liu, X, Nelson, D.W., Hull, A.K., Grahn, M., Clayton, M.K. and Ney, D.M. Lim, K., van Calcar, S.C., Nelson, K.L., Gleason, S.T. and Ney, D.M. Acceptable low- Liu, X., Nelson, D.W., Holst, J.J., and Ney, D.M. Synergistic effect of supplemental enteral nutrients and glucagon-like peptide-2 on intestinal adaptation in a rat model of short bowel syndrome. Am. J. Clin. Nutr. 84:R1142-R1150, 2006. Nelson, D.W., Liu, X., Holst, J.J., Raybould, H.E. and Ney, D.M. Vagal afferents are essential for maximal resection-induced intestinal adaptive growth in orally fed rats. Am. J. Physiol. 291:R1256-R1264, 2006. |
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Short bowel syndrome often requires permanent TPN due to inadequate intestinal adaptation. The mechanisms underlying intestinal adaptation are poorly understood. Using a rat model for human short bowel syndrome, we have shown that coinfusion of IGF-I with TPN solution stimulates structural and functional adaptation of the residual jejunum and permits transition to enteral feeding, see Figure 1. This suggests that IGF-I or other intestinotrophic agents may improve intestinal function in humans with TPN-dependent short bowel syndrome. Current experiments are investigating the neuroendocrine pathways that mediate intestinal adaptation to resection and the intestinotrophic effects of IGF-I and GLP-2.
GLP-2 is a potent intestinal growth factor whose synthesis is nutrient dependent. It is a product of the proglucagon gene synthesized in the enteroendocrine L-cells of the distal intestine, see Figure 2. GLP-2 receptors (GLP-2R) have been localized to the brain and gastrointestinal tract with a greater concentration of GLP-2R in the proximal compared to the distal bowel.